The first Wait Wait... Don't Tell Me! collection focused on the best of the "Not My Job" segment of the program. This second collection skims the cream off the entire archive of the show, with selections from "Who's Carl This Time?", "Lightning Fill in the Blank", "The Listener Limerick Challenge", "Not My Job!" and more.

Panelists include author and humorist Roy Blount Jr., author and radio anomaly Tom Bodett, syndicated advice Amy Dickinson ("Ask Amy"), journalist P.J. O'Rourke, Washington Post columnist Roxanne Roberts, Boston Globe writer Charlie Pierce, comedian Paula Poundstone, and television personality Mo Rocca.

Wait Wait... Don't Tell Me! is NPR's "oddly informative" weekly hour-long news quiz program. Over 1.8 million listeners on over 332 stations nationwide turn in to hear host PETER SAGAL lead a group of panelists and listeners through a series of games designed to test their knowledge of the week's news — and showcase their wit. NPR newscaster CARL KASELL serves as judge and scorekeeper. When not touring, the program is recorded at the Bank One Auditorium in Chicago.